275 Clinical Significance of T Lymphocyte Subsets and Hla-dr in Peripheral Blood of Patients

Objective: To observe the variation of T lymphocyte subsets and human histocompatibility antigen (HLA-DR) in peripheral blood of patients with severe preeclampsia(SPE). Method: Peripheral blood from 30 patients with SPE (SPE group), 30 healthy pregnant women (healthy pregnant group) and 18 healthy un-pregnant women (healthy un-pregnant group) was a collected.The percentage of CD4T, CD8T and HLA-DR in each group were compared by Flow cytometry (FCM). Results: There was no difference in the expression of CD4T in each group ((35.6±5.4)%VS (37.8±8.9), (35.6±5.4)%VS(37.1±9.6)%). The expression of CD8 T in SPE group was significantly higher than those in the healthy pregnant group ((32.1±7.4)% VS(26.9±7.7)%, P<0.01) and in the healthy un-pregnant group ((32.1±7.4)% VS(25.4±7.6)%, P<0.01). The expression of HLA-DR in SPE group was significantly lower than that in healthy pregnant group ((43.7±12.7)% VS(58.3±13.9)%;P<0.01). Conclusions: Higher expression of CD8T was found in peripheral blood of SPE patients which lead to T lymphocyte subsets imbalance. The decrease of HLA-DR may contribute to the pathologic process of SPE.